Josephine F Trott, Ph.D.

Josephine Trott

Position Title
Associate Project Scientist

Unit
Current Research Staff

Meyer 1411
Bio

Education

BScAgr (Hons, Convocation Medal, University Medal) (Agricultural Genetics major), University of Sydney, Australia

PhD, Zoology and Molecular Biology, University of Melbourne, Australia

Research

Evaluation of the offspring of a gene edited polled bull

Publications

Kim K, Trott JF, Gao G, Chapman A, Weiss RH. Plasma metabolites and lipids associate with kidney function and kidney volume in hypertensive ADPKD patients early in the disease course. BMC Nephrol. 2019 Feb 25;20(1):66. doi: 10.1186/s12882-019-1249-6. PubMed PMID: 30803434.

Trott JF, Hwang VJ, Ishimaru T, Chmiel KJ, Zhou JX, Shim K, Stewart BJ, Mahjoub MR, Jen KY, Barupal DK, Li X, Weiss RH. Arginine reprogramming in ADPKD results in arginine-dependent cystogenesis. Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1855-F1868. doi: 10.1152/ajprenal.00025.2018. Epub 2018 Oct 3. PubMed PMID: 30280600; PubMed Central PMCID: PMC6336982.

Berryhill GE, Trott JF, Derpinghaus AL, Hovey RC. TRIENNIAL LACTATION SYMPOSIUM/BOLFA: Dietary regulation of allometric ductal growth in the mammary glands. J Anim Sci. 2017 Dec;95(12):5664-5674. doi: 10.2527/jas2017.1901. Review. PubMed PMID: 29293798; PubMed Central PMCID: PMC6292269.

Abu Aboud O, Habib SL, Trott J, Stewart B, Liang S, Chaudhari AJ, Sutcliffe J, Weiss RH. Glutamine Addiction in Kidney Cancer Suppresses Oxidative Stress and Can Be Exploited for Real-Time Imaging. Cancer Res. 2017 Dec 1;77(23):6746-6758. doi: 10.1158/0008-5472.CAN-17-0930. Epub 2017 Oct 11. PubMed PMID: 29021138; PubMed Central PMCID: PMC5791889.
 
Hwang VJ, Zhou X, Chen X, Trott J, Abu Aboud O, Shim K, Dionne LK, Chmiel KJ, Senapedis W, Baloglu E, Mahjoub MR, Li X, Weiss RH. Anticystogenic activity of a small molecule PAK4 inhibitor may be a novel treatment for autosomal dominant polycystic kidney disease. Kidney Int. 2017 Oct;92(4):922-933. doi: 10.1016/j.kint.2017.03.031. Epub 2017 May 23. PubMed PMID: 28545714; PubMed Central PMCID: PMC5610616.

Berryhill GE, Lemay DG, Trott JF, Aimo L, Lock AL, Hovey RC. The Transcriptome of Estrogen-Independent Mammary Growth in Female Mice Reveals That Not All Mammary Glands Are Created Equally. Endocrinology. 2017 Oct 1;158(10):3126-3139. doi: 10.1210/en.2017-00395. PubMed PMID: 28938404; PubMed Central PMCID: PMC5659702.

Mori H, Chen JQ, Cardiff RD, Pénzváltó Z, Hubbard NE, Schuetter L, Hovey RC, Trott JF, Borowsky AD. Pathobiology of the 129:Stat1 -/- mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype. Breast Cancer Res. 2017 Sep 2;19(1):102. doi: 10.1186/s13058-017-0892-8. PubMed PMID: 28865492; PubMed Central PMCID: PMC5581425.

Chen CH, Fong LWR, Yu E, Wu R, Trott JF, Weiss RH. Upregulation of MARCKS in kidney cancer and its potential as a therapeutic target. Oncogene. 2017 Jun 22;36(25):3588-3598. doi: 10.1038/onc.2016.510. Epub 2017 Feb 6. PubMed PMID: 28166200; PubMed Central PMCID: PMC5926797.

Berryhill GE, Miszewski SG, Trott JF, Kraft J, Lock AL, Hovey RC. Trans-Fatty Acid-Stimulated Mammary Gland Growth in Ovariectomized Mice is Fatty Acid Type and Isomer Specific. Lipids. 2017 Mar;52(3):223-233. doi: 10.1007/s11745-016-4221-2. Epub 2017 Jan 10. PubMed PMID: 28074319.

Trott JF, Kim J, Abu Aboud O, Wettersten H, Stewart B, Berryhill G, Uzal F, Hovey RC, Chen CH, Anderson K, Graef A, Sarver AL, Modiano JF, Weiss RH. Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. Oncotarget. 2016 Oct 11;7(41):66540-66557. doi: 10.18632/oncotarget.11658. PubMed PMID: 27572319; PubMed Central PMCID: PMC5341819.

VanKlompenberg MK, Manjarín R, Donovan CE, Trott JF, Hovey RC. Regulation and localization of vascular endothelial growth factor within the mammary glands during the transition from late gestation to lactation. Domest Anim Endocrinol. 2016 Jan;54:37-47. doi: 10.1016/j.domaniend.2015.09.003. Epub 2015 Sep 25. PubMed PMID: 26490114.
 
Berryhill GE, Trott JF, Hovey RC. Mammary gland development--It's not just about estrogen. J Dairy Sci. 2016 Jan;99(1):875-83. doi: 10.3168/jds.2015-10105. Epub 2015 Oct 23. Review. PubMed PMID: 26506542; PubMed Central PMCID: PMC5068565.

Rowson-Hodel AR, Manjarin R, Trott JF, Cardiff RD, Borowsky AD, Hovey RC. Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. BMC Cancer. 2015 Jul 31;15:562. doi: 10.1186/s12885-015-1572-7. PubMed PMID: 26228788; PubMed Central PMCID: PMC4520266.

Schennink A, Trott JF, Berryhill GE, Donovan CE, Manjarin R, VanKlompenberg MK, Rowson-Hodel AR, Luis MY, Hovey RC. Alcohol intake stimulates epithelial proliferation in an authentic model of the human breast. Reprod Toxicol. 2015 Jul;54:93-100. doi: 10.1016/j.reprotox.2014.10.020. Epub 2014 Nov 1. PubMed PMID: 25450420.

Wettersten HI, Hakimi AA, Morin D, Bianchi C, Johnstone ME, Donohoe DR, Trott JF, Aboud OA, Stirdivant S, Neri B, Wolfert R, Stewart B, Perego R, Hsieh JJ, Weiss RH. Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis. Cancer Res. 2015 Jun 15;75(12):2541-52. doi: 10.1158/0008-5472.CAN-14-1703. Epub 2015 May 7. PubMed PMID: 25952651; PubMed Central PMCID: PMC4470795.

Chen JQ, Mori H, Cardiff RD, Trott JF, Hovey RC, Hubbard NE, Engelberg JA, Tepper CG, Willis BJ, Khan IH, Ravindran RK, Chan SR, Schreiber RD, Borowsky AD. Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent. PLoS One. 2015 Jun 15;10(6):e0129895. doi: 10.1371/journal.pone.0129895. eCollection 2015. PubMed PMID: 26075897; PubMed Central PMCID: PMC4468083.

Schennink A, Trott JF, Manjarin R, Lemay DG, Freking BA, Hovey RC. Comparative genomics reveals tissue-specific regulation of prolactin receptor gene expression. J Mol Endocrinol. 2015 Feb;54(1):1-15. doi: 10.1530/JME-14-0212. Epub 2014 Oct 30. PubMed PMID: 25358647.

Trott JF, Freking BA, Hovey RC. Variation in the coding and 3' untranslated regions of the porcine prolactin receptor short form modifies protein expression and function. Anim Genet. 2014 Feb;45(1):74-86. doi: 10.1111/age.12100. Epub 2013 Dec 18. PubMed PMID: 24350599.

Schennink A, Trott JF, Freking BA, Hovey RC. A novel first exon directs hormone-sensitive transcription of the pig prolactin receptor. J Mol Endocrinol. 2013 May 9;51(1):1-13. doi: 10.1530/JME-12-0234. Print 2013. PubMed PMID: 23576686.
 
Vanklompenberg MK, Manjarin R, Trott JF, McMicking HF, Hovey RC. Late gestational hyperprolactinemia accelerates mammary epithelial cell differentiation that leads to increased milk yield. J Anim Sci. 2013 Mar;91(3):1102-11. doi: 10.2527/jas.2012-5903. Epub 2013 Jan 7. PubMed PMID: 23296835.
 
Berryhill GE, Gloviczki JM, Trott JF, Aimo L, Kraft J, Cardiff RD, Paul CT, Petrie WK, Lock AL, Hovey RC. Diet-induced metabolic change induces estrogen-independent allometric mammary growth. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16294-9. doi: 10.1073/pnas.1210527109. Epub 2012 Sep 17. PubMed PMID: 22988119; PubMed Central PMCID: PMC3479619.

Trott JF, Schennink A, Petrie WK, Manjarin R, VanKlompenberg MK, Hovey RC. Triennial Lactation Symposium: Prolactin: The multifaceted potentiator of mammary growth and function. J Anim Sci. 2012 May;90(5):1674-86. doi: 10.2527/jas.2011-4682. Epub 2011 Dec 28. Review. PubMed PMID: 22205663.

Trott JF, Schennink A, Hovey RC. Cloning and expression of a unique short form of the porcine prolactin receptor. J Mol Endocrinol. 2011 Jan 19;46(1):51-62. doi: 10.1677/JME-10-0101. Print 2011 Feb. PubMed PMID: 21147947.
 
Horigan KC, Trott JF, Barndollar AS, Scudder JM, Blauwiekel RM, Hovey RC. Hormone interactions confer specific proliferative and histomorphogenic responses in the porcine mammary gland. Domest Anim Endocrinol. 2009 Aug;37(2):124-38. doi: 10.1016/j.domaniend.2009.04.002. Epub 2009 May 26. PubMed PMID: 19497700.
 
Trott JF, Horigan KC, Gloviczki JM, Costa KM, Freking BA, Farmer C, Hayashi K, Spencer T, Morabito JE, Hovey RC. Tissue-specific regulation of porcine prolactin receptor expression by estrogen, progesterone, and prolactin. J Endocrinol. 2009 Jul;202(1):153-66. doi: 10.1677/JOE-08-0486. Epub 2009 Apr 28. PubMed PMID: 19401343.

Morabito JE, Trott JF, Korz DM, Fairfield HE, Buck SH, Hovey RC. A 5' distal palindrome within the mouse mammary tumor virus-long terminal repeat recruits a mammary gland-specific complex and is required for a synergistic response to progesterone plus prolactin. J Mol Endocrinol. 2008 Aug;41(2):75-90. doi: 10.1677/JME-08-0027. Epub 2008 Jun 4. PubMed PMID: 18524869.

Trott JF, Vonderhaar BK, Hovey RC. Historical perspectives of prolactin and growth hormone as mammogens, lactogens and galactagogues--agog for the future! J Mammary Gland Biol Neoplasia. 2008 Mar;13(1):3-11. doi: 10.1007/s10911-008-9064-x. Epub 2008 Jan 19. Review. PubMed PMID: 18204889.

Trott JF, Farley NR, Taatjes DJ, Hovey RC. Cloning and functional characterization of allelic variation in the porcine prolactin receptor. Domest Anim Endocrinol. 2007 Oct;33(3):313-34. Epub 2006 Jul 31. PubMed PMID: 16905289.

Trott JF, Adams TE, Wilson M, Nicholas KR. Positive and negative regulatory elements in the late lactation protein-A gene promoter from the tammar wallaby (Macropus eugenii). Biochim Biophys Acta. 2005 Apr 5;1728(1-2):65-76. PubMed PMID: 15777715.

Goldhar AS, Vonderhaar BK, Trott JF, Hovey RC. Prolactin-induced expression of vascular endothelial growth factor via Egr-1. Mol Cell Endocrinol. 2005 Mar 31;232(1-2):9-19. PubMed PMID: 15737464.

Greene EA, Trott JF. The Self-Guided Horse Facility Analysis: A Proactive Safety Education Tool for Equine Facilities. Journal of extension. 2004; 42(6). Edit citation
 
Trott JF, Hovey RC, Koduri S, Vonderhaar BK. Multiple new isoforms of the human prolactin receptor gene. Adv Exp Med Biol. 2004;554:495-9. PubMed PMID: 15384631.
 
Hovey RC, Trott JF. Morphogenesis of mammary gland development. Adv Exp Med Biol. 2004;554:219-28. Review. PubMed PMID: 15384579.

Trott JF, Simpson KJ, Moyle RL, Hearn CM, Shaw G, Nicholas KR, Renfree MB. Maternal regulation of milk composition, milk production, and pouch young development during lactation in the tammar wallaby (Macropus eugenii ). Biol Reprod. 2003 Mar;68(3):929-36. PubMed PMID: 12604644.

Trott JF, Hovey RC, Koduri S, Vonderhaar BK. Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein. J Mol Endocrinol. 2003 Feb;30(1):31-47. PubMed PMID: 12580759.

Trott JF, Wilson MJ, Hovey RC, Shaw DC, Nicholas KR. Expression of novel lipocalin-like milk protein gene is developmentally-regulated during lactation in the tammar wallaby, Macropus eugenii. Gene. 2002 Jan 23;283(1-2):287-97. PubMed PMID: 11867236.

Hovey RC, Trott JF, Vonderhaar BK. Establishing a framework for the functional mammary gland: from endocrinology to morphology. J Mammary Gland Biol Neoplasia. 2002 Jan;7(1):17-38. Review. PubMed PMID: 12160083.

Hovey RC, Trott JF, Ginsburg E, Goldhar A, Sasaki MM, Fountain SJ, Sundararajan K, Vonderhaar BK. Transcriptional and spatiotemporal regulation of prolactin receptor mRNA and cooperativity with progesterone receptor function during ductal branch growth in the mammary gland. Dev Dyn. 2001 Oct;222(2):192-205. PubMed PMID: 11668597.

Nicholas KR, Fisher JA, Muths E, Trott J, Janssens PA, Reich C, Shaw DC. Secretion of whey acidic protein and cystatin is down regulated at mid-lactation in the red kangaroo (Macropus rufus). Comp Biochem Physiol A Mol Integr Physiol. 2001 Jul;129(4):851-8. PubMed PMID: 11440871.

Nicholas K, Simpson K, Wilson M, Trott J, Shaw D. The tammar wallaby: a model to study putative autocrine-induced changes in milk composition. J Mammary Gland Biol Neoplasia. 1997 Jul;2(3):299-310. Review. PubMed PMID: 10882313.

Campbell PM, Trott JF, Claudianos C, Smyth KA, Russell RJ, Oakeshott JG. Biochemistry of esterases associated with organophosphate resistance in Lucilia cuprina with comparisons to putative orthologues in other Diptera. Biochem Genet. 1997 Feb;35(1-2):17-40. PubMed PMID: 9238516.